Ansley Jones
September 22, 2015
“Bionic Eyes, Stem Cells and Gene Therapy: 3 Cutting Edge Cures for Blindness” by Alexandra Sifferlin
Medical advances in the past few years have been revolutionary and life changing for people affected by various diseases, but not all diseases have made big leaps forward. Ophthalmologists (eye doctors) have known for a long time that eyes pick up light and turn it into electrical signals that are sent to the brain where it is generated into an image. Yet, this process is extremely complicated and many things can go wrong along the way between the eye and the brain. Ophthalmologists know a lot more about vision problems and their causes; however, for those with irreversible blindness, there is has not been much hope until now. Researchers are getting closer to being able to effectively treat blindness. This article discusses three cases where patients were treated with cutting-edge cures for blindness. The first patient, Steve McMillin, was blind due to retinitis pigmentosa. This rare and inherited disease destroys photoreceptors that take in light and transmit signals to the brain. McMillin was treated using the Argus-II, a “bionic eye.” The Argus-II is a retinal implant that is surgically implanted into a patient’s eye. The patient wears a pair of modified sunglasses that have a video camera on the front of them. The camera picks up an image and transmits it to a processing unit on the glasses, which then transmits the impulse to the retinal implant. The implant then sends the signal past the destroyed photoreceptors to healthy retinal cells that send the signal to the brain so it can then see the image. The patient has to undergo training in order for the brain to get used to the Argus-II and to be able to see images better; it does not happen automatically. McMillin was not able to work after his eyesight disappeared. He received the Argus-II treatment and can now see wavy-lines and edges, but not full shapes. With training, he should continue to make progress. The second patient, Michael Ganley, is losing his vision due to Stargardt’s macular degeneration. This disease is the main cause of blindness in elderly people but Stargardt’s disease is the juvenile form. Macular degeneration causes the cells that feed the retina to degrade, causing the retina to die. The eye then cannot take in light and process signals to send to the brain. Michael Ganley was treated using stem cells from extra IVF embryos. These stem cells were treated with compounds to influence them to grow into retinal pigment epithelial cells, the cells that feed the retina. The stem cells were then injected into the eye where they will theoretically grow and replace the damaged feeding cells. Ganley has not noticed if the procedure has made a huge improvement yet, but a couple weeks after his surgery he could see two more lines on the eye chart. The cells take a while to grow and repair the retina, so his condition could continue to get better with time instead of getting worse. The third patient, Dale Turner, has Leber congenital amaurosis, a disease caused by a genetic mutation that inhibits the photoreceptors in the eyes. He received a gene therapy treatment where a harmless virus carrying non-mutated genes producing the right proteins was injected into his retina. This treatment is not always permanent for some patients because their retinas continue to degenerate. Scientists are continuing to modify this procedure to improve results. Turner received this treatment and remembers being shocked by how blue the sky was; he didn’t realize how much he was missing out on because of his condition.
Having good vision is directly correlated to quality of life. Poor vision makes it harder to work, live independently, and enjoy many everyday activities. Each patient struggled to do something important in their lives because of their blindness. Steve McMillin, the first patient, could see his wife’s face and his grandson for the first time in years after his vision loss. Michael Ganley, the second patient, said his poor vision had a direct impact on his fiance, who went through the whole process with him. Dale Turner, the third patient, pointed out that by not being able to see, he missed out on so many things. Turner accurately stated, “It isn’t easy. We live in a society that assumes everybody can hear and everybody can see. So the prospect of being able to see and overcoming something that’s supposed to be incurable is remarkable.” As these technologies improve, they become less expensive and more widely available to other patients. Eventually this can help those who are blind in developing worlds. Cataracts and eye infections plague people in third-world countries. I did a health fellowship in eye care this summer in Ghana, and experienced first hand how people are affected by poor eyesight. They receive little support from local clinics and their eyesight prevents them from being able to work and take care of their families. Some even saw traditional healers who treated their eye problems with urine and dirt. If an adult can’t see then a child in the family is often kept out of school to be their eyes so it impacts the lives of other family members and eventually the whole community. If scientists can develop these treatments at a reasonable cost, we could eliminate most blindness, improving the lives of people around the world.
I found this article to be fascinating. It was very detailed in describing the three patients’ individual cases and ground-breaking treatments. Each case study had the diagnosis, causes, treatment, how the treatment works, and what it has done for the patient. This made the article especially impactful because it was personal as well as scientific. The one thing Sifferlin, the author, could have done better would be to define and explain some of the scientific terms. I learned about eyes in my fellowship so I was familiar with some of the technical terms but someone with no background in the anatomy of eyes and how they work would find the article difficult to read and understand. Other than that, this article was thorough and unbelievably interesting. Imagine the possibilities if blindness could be treated and cured someday?