Previous Unknown Mechanism of Memory Formation Discovered

            The article “Previous Unknown Mechanism of Memory Formation Discovered” discusses the role of unique molecules known as microRNAs in memory formation. MicroRNAs were previously associated with protein production, but Courtney Miller’s researches have revealed their bigger roles. Miller’s research revolved around the rapid genetic testing on a large scale of a human while learning was occurring. Results revealed that the level of microRNAs decreased while learning was occurring. Such suppression of microRNAs is a main supporting factor in the formation of long-term memory in the amygdale of the brain and also in regulating protein synthesis during memory consolidation. More than half of all known MicroRNAs (specifically, miR-182) are found in amygdale of the human brain. The MicroRNAs are also significant in repressing (DNA binding) proteins that control actin, which is a major component of cytoskeleton. Cytoskeleton holds the cells together.

           

           This article reveals an interesting and important study about human memory. This research remains rudimentary at most, and the majority of the memory formation process remains a mystery to us. For instance, we are still not sure how the suppression of microRNAs formulates memory. However, this research still has immense medical significance. Miller has stated that she will look more deeply into the correlation between memory loss at old ages and accumulation of microRNAs. Overexpression is thought to prevent not only the formation of memory but also lead to a decrease in the ability to adapt to changes. Thus, finding the methods for regulating the amount of microRNAs could be a revolutionary step in the medical field.

            This article was overall well-written, but was confusing at some points. This was mainly because the author incorporated many specific, advanced medical terms without giving their definitions. The part about microRNA’s role in regulating cytoskeleton was especially confusing and seemed irrelevant to memory formation. 

The Scripps Research Institute. "Previously Unknown Mechanism of Memory Formation Discovered." ScienceDaily, 30 Jan. 2013. Web. 30 Jan. 2013.

 

posted for E. Choi