Cindy Kwok
Sept 27, 2017
“Cellular 'message in a bottle' may provide path to new way of treating disease.” ScienceDaily,
ScienceDaily, www.sciencedaily.com/releases/2017/09/170927093316.htm. Accessed 27
Sept. 2017.
Cellular 'message in a bottle' may provide path to new way of treating disease
The article I read was called “Cellular ‘message in a bottle’ may provide path to new way of treating disease” from the Harvard T.H. Chan School of Public Health. It was about the finding of a new extracellular vesicle, which is a “sac secreted from cells that contains proteins and RNA molecules”, called ARMMs. Extracellular vesicles are many times more numerous than the number of cells in our body. ARMMs differ from the previous extracellular vesicles due to the way it was formed and what it can potentially do. ARMMs are secreted from the cell’s plasma membrane. It has a unique ability to “facilitate NOTCH receptor signalling at a distance”. NOTCH is a type of intercellular communication. Because NOTCH generally requires cell to cell contact, the vesicle’s ability to activate it without touching is central in the role it can play in future health. Some ideas that biologists are thinking about is swapping molecules inside of ARMMs for antibodies, and using it to direct towards specific cells and tissues in the body.
I think this article did a great job describing the potential use of ARMMs in the future. I especially enjoyed how senior author Quan Lu talked about the path that this new discovery can lead to. He describes his idea of directing ARMMs inside the body, but claims that it won’t be at least until 10 years later with sufficient research to even put the idea to use. One part I thought the article could do better on was describing the multiple ways to put the discovery to use. This may seem contradictory as I previously claimed to like this part of the article. However, the article ONLY points out the use of ARMMs from Lu’s point of view, meanwhile briefly mentioning how Lu’s idea differed from that of other researchers who were also researching extracellular vesicles. I thought the article could go more in depth about the other researchers because it may be interesting to see how their ideas could potentially combine.
This article in general was extremely interesting. I liked how it talked about ways this new discovery can lead to such a large impact on humans in the future, but emphasizes on how there is still lots of research to be done. When research is done however, this discovery can lead to easier ways of navigating antibodies and vaccines into the body and targeting specific areas, which has always been an obstacle.